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Gene set enrichment analysis indicated that the identified candidate genes were related to biological processes and functional terms that were involved in growth and lipid metabolism.

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Integrating Single-Step GWAS and Bipartite Networks Reconstruction Provides Novel Insights into Yearling Weight and Carcass Traits in Hanwoo Beef Cattle.

Received: 25 August 2020 Revised: 2 October 2020 Accepted: 6 October 2020 Published: 9 October 2020.

Hanwoo is an indigenous cattle breed in Korea and popular for meat production owing to its rapid growth and high-quality meat.

Its yearling weight and carcass traits (backfat thickness, carcass weight, eye muscle area, and marbling score) are economically important for the selection of young and proven bulls.

In recent decades, the advent of high throughput genotyping technologies has made it possible to perform genome-wide association studies (GWAS) for the detection of genomic regions associated with traits of economic interest in different species.

In this study, we conducted a weighted single-step genome-wide association study which combines all genotypes, phenotypes and pedigree data in one step (ssGBLUP).

Our results revealed 33 relevant genomic regions related to the traits of interest.